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What is the difference between mifepristone and misoprostol?

Mifepristone blocks the activity of progesterone (a hormone needed to maintain a pregnancy) in the uterus and softens the cervix so the pregnancy comes out more easily. Misoprostol makes the uterus contract and push out the pregnancy. This is similar to what happens when a person has a miscarriage.

When both medications are available, mifepristone is taken first, and then misoprostol is taken 1–2 days later. Mifepristone is always swallowed. Misoprostol is put in the mouth to dissolve, either in between the cheek and gum or under the tongue. Note: You don’t need to take misoprostol vaginally, and no one ever needs to insert it for you.

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